Diazabicyclooctane Functionalization for Inhibition of β-Lactamases from Enterobacteria
نویسندگان
چکیده
منابع مشابه
Metallo-β-Lactamases and Aptamer-Based Inhibition
An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the hydrolysis of the β-lactam bond of this class of antibiotics, by pathogenic bacteria such as Bacillus cereus, are rendering them useless. Some inh...
متن کاملThe New β-Lactamases
From the Department of Infectious Diseases, Lahey Clinic, Burlington, Mass., and Harvard Medical School, Boston (G.A.J.); and the Department of Geographic Medicine and Infectious Diseases, Tufts–New England Medical Center and Tufts University School of Medicine, Boston (L.S.M.-P.). Address reprint requests to Dr. Jacoby at Lahey Clinic, 41 Mall Rd., Burlington, MA 01805, or at george.a.jacoby@l...
متن کاملCharacterization of β-Lactamases from Urinary Isolates of Escherichia coli in Tehran
Knowledge of antimicrobial resistance patterns in E. coli, the predominant pathogen associated with urinary tract infections (UTI) is important as a guide in selecting empirical antimicrobial therapy. Methods: To describe the antimicrobial susceptibility of E. coli associated with UTI in a major university hospital in Tehran (Iran), seventy-six clinical isolates of E. coli were studied for susc...
متن کاملβ-lactamases produced by amoxicillin-clavulanate-resistant enterobacteria isolated in Buenos Aires, Argentina: a new blaTEM gene.
Resistance to β-lactam/β-lactamase inhibitors in enterobacteria is a growing problem that has not been intensively studied in Argentina. In the present work, 54/843 enterobacteria collected in a teaching hospital of Buenos Aires city were ampicillin-sulbactam-resistant isolates remaining susceptible to second- and third-generation cephalosporins. The enzymatic mechanisms present in the isolates...
متن کاملEmergence of metallo-β-lactamases in Enterobacteriaceae from Argentina.
Carbapenem susceptibility in Enterobacteriaceae (M9921, M9959) revealed the presence of MBLs bla(VIM-2) (M9959) and bla(IMP-8) (M9921), both as first cassettes of class-1-integrons. ESBL bla(PER-2) was detected in both strains and M9921 also harboured qnrB10, aac(6')-Ib and aac(6')-Ib-cr. This is the first report of MBLs in Enterobacteriaceae from Argentina.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2020
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.9b02125